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Along with our experienced Patient Support Managers, here are other resources to help you:

Resources for PYRUKYND® (mitapivat) tablets

About PYRUKYND Brochure

Get all the details on PYRUKYND and how it may help your PK deficiency. Also, get tools to help you work closely with your doctor.

Download brochure

Explore the PYRUKYND website to learn all about how PYRUKYND works, how to take it, and how it could help you.

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PYRUKYND Treatment Journal

Log your notes in a journal that’s designed to help you track your PK deficiency and treatment with PYRUKYND.

Download journal
PYRUKYND Patient Dosage Guide

Keep this guide handy for a quick reminder on how and when to take PYRUKYND, once you’ve been prescribed.

Download guide
myAgios Patient Brochure

Get the details on myAgios Patient Support Services and how a Patient Support Manager can help throughout your PK deficiency journey.

Download guide

Want to connect with a community of people who have PK deficiency?

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We’re ready when you are.

Get answers by calling your Patient Support Manager at 1-800-951-3889, Mon-Fri, 8 AM to 6 PM, ET


PYRUKYND is a prescription medicine used to treat low red blood cell counts caused by the early breakdown of red blood cells (hemolytic anemia) in adults with pyruvate kinase (PK) deficiency.

It is not known if PYRUKYND is safe and effective in children.


PYRUKYND may cause serious side effects, including:

  • Rapid breakdown of red blood cells (acute hemolysis) has happened after suddenly interrupting or stopping treatment with PYRUKYND. You should not suddenly stop taking PYRUKYND. If you have to stop your treatment with PYRUKYND, your healthcare provider should monitor you closely. Tell your healthcare provider right away if you develop any signs or symptoms of breakdown of red blood cells including yellowing of the skin or the whites of your eyes (jaundice), dark colored urine, dizziness, confusion, feeling tired, or shortness of breath

The most common side effects of PYRUKYND were decrease in reproductive hormone (estrone) in men, increased salt from uric acid (urate) blood test, back pain, decrease in reproductive hormone (estradiol) in men, and joint pain (arthralgia).

These are not all the possible side effects of PYRUKYND. Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before taking PYRUKYND, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems

  • are pregnant or plan to become pregnant. It is not known if PYRUKYND will harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think that you are pregnant during treatment with PYRUKYND

  • are breastfeeding or plan to breastfeed. It is not known if PYRUKYND passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with PYRUKYND

Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. PYRUKYND and certain other medicines may affect each other causing side effects. PYRUKYND may affect the way other medicines work, and other medicines may affect how PYRUKYND works. Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.

Please see Full Prescribing Information, including Patient Information.