Get the rundown on financial support programs for PYRUKYND® (mitapivat) tablets

If you’re eligible for financial support, we can help you find programs for accessing PYRUKYND. Our Patient Support Managers will guide you every step of the way—from enrollment forms to insurance questions and challenges.

If you have commercial insurance:

What is commercial insurance?

Commercial insurance is health insurance that comes through your work or your spouse’s work, or that you purchase yourself through the marketplace.

The PYRUKYND Copay Program: Pay no more than $0 if you’re eligible

You may pay no more than $0 for each prescription of PYRUKYND, regardless of how much you make. Support is available for those who qualify. Talk to your doctor about applying if you’ve been prescribed PYRUKYND.

Note: If you have government insurance, you are not eligible for this program.

Please see full Terms and Conditions for more information.

If you have a temporary loss or gap in coverage, you may be eligible for a free product program. Contact myAgios Patient Support Services for more information at 1-800-951-3889.

If you have government insurance:

What is government insurance?

Government insurance is insurance through a government program like Medicare, Medicaid, Tricare, and some retiree plans.

Independent foundations may be able to help

Independent foundations may be available to help you with out-of-pocket expenses. myAgios or our specialty pharmacy can provide more information.

Agios is not affiliated with these organizations.

Please see full Terms and Conditions for more information.

If you are uninsured or underinsured:

What does it mean to be uninsured or underinsured?

You do not have insurance, or your insurance plan does not cover PYRUKYND (may apply to commercial or government insurance).

The Patient Assistance Program (PAP) may be able to help you access PYRUKYND, if you are eligible.

Income restrictions apply. You and your doctor can reach out to myAgios to learn more.

Please see full Terms and Conditions for more information.

If you have an interruption in health insurance coverage:

Access for coverage interruption.

This program offers temporary access to free product to eligible patients.

Patients participating in government healthcare insurance are not eligible.

If you have a prescription and approval from your insurance:

PYRUKYND fulfillment and delivery.

The specialty pharmacy will fulfill your prescription. If your doctor and insurance company determine you are eligible for treatment, we will deliver PYRUKYND to your door.

Want to see how we can help once you’re on treatment?

Let’s see

We’re ready when you are.

Get answers by calling your Patient Support Manager at 1-800-951-3889, Mon-Fri, 8 AM - 6 PM, ET


PYRUKYND is a prescription medicine used to treat low red blood cell counts caused by the early breakdown of red blood cells (hemolytic anemia) in adults with pyruvate kinase (PK) deficiency.

It is not known if PYRUKYND is safe and effective in children.


PYRUKYND may cause serious side effects including:

  • Rapid breakdown of red blood cells (acute hemolysis) has happened after suddenly interrupting or stopping treatment with PYRUKYND. You should not suddenly stop taking PYRUKYND. If you have to stop your treatment with PYRUKYND, your healthcare provider should monitor you closely. Tell your healthcare provider right away if you develop any signs or symptoms of breakdown of red blood cells including yellowing of the skin or the whites of your eyes (jaundice), dark colored urine, dizziness, confusion, feeling tired, or shortness of breath

The most common side effects of PYRUKYND were decrease in reproductive hormone (estrone) in men, increased salt from uric acid (urate) blood test, back pain, decrease in reproductive hormone (estradiol) in men, and joint pain (arthralgia).

These are not all the possible side effects of PYRUKYND. Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or

Before taking PYRUKYND, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems
  • are pregnant or plan to become pregnant. It is not known if PYRUKYND will harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think that you are pregnant during treatment with PYRUKYND
  • are breastfeeding or plan to breastfeed. It is not known if PYRUKYND passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with PYRUKYND

Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. PYRUKYND and certain other medicines may affect each other causing side effects. PYRUKYND may affect the way other medicines work, and other medicines may affect how PYRUKYND works. Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.

Please see full Prescribing Information, including Patient Information.