Dedicated Patient Support Managers are here for you

What happens when you have a Patient Support Manager on your PYRUKYND team? You get personal support.

Your Patient Support Manager will get to know you and your story with pyruvate kinase (PK) deficiency. You’ll chat with them and they’ll listen to your concerns and understand what you’re looking for. Then, they can provide tools to help you understand PK deficiency and treatment with PYRUKYND® (mitapivat) tablets.

Meet our Patient Support Managers

Connect with others with PK deficiency through patient webinar programs, regardless of treatment status.

The purpose of this program is NOT to offer medical or treatment-related advice. For these types of questions, contact your doctor.

No matter where you are in your journey, our Patient Support Managers can help with all sorts of questions, including:

A Patient Support Manager is available to answer questions and share tips on having discussions with your treatment team.*

*PSMs will be coordinating with the Specialty Pharmacy and can discuss product characteristics (eg, dosing, delivery of product to you, report any side effects you may experience, etc).

Want to connect with a community of people who have PK deficiency?

Tell me how

We’re ready when you are.

Get answers by calling your Patient Support Manager at 1-800-951-3889, Mon-Fri, 8 AM to 6 PM, ET


PYRUKYND is a prescription medicine used to treat low red blood cell counts caused by the early breakdown of red blood cells (hemolytic anemia) in adults with pyruvate kinase (PK) deficiency.

It is not known if PYRUKYND is safe and effective in children.


PYRUKYND may cause serious side effects, including:

  • Rapid breakdown of red blood cells (acute hemolysis) has happened after suddenly interrupting or stopping treatment with PYRUKYND. You should not suddenly stop taking PYRUKYND. If you have to stop your treatment with PYRUKYND, your healthcare provider should monitor you closely. Tell your healthcare provider right away if you develop any signs or symptoms of breakdown of red blood cells including yellowing of the skin or the whites of your eyes (jaundice), dark colored urine, dizziness, confusion, feeling tired, or shortness of breath

The most common side effects of PYRUKYND were decrease in reproductive hormone (estrone) in men, increased salt from uric acid (urate) blood test, back pain, decrease in reproductive hormone (estradiol) in men, and joint pain (arthralgia).

These are not all the possible side effects of PYRUKYND. Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or

Before taking PYRUKYND, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems

  • are pregnant or plan to become pregnant. It is not known if PYRUKYND will harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think that you are pregnant during treatment with PYRUKYND

  • are breastfeeding or plan to breastfeed. It is not known if PYRUKYND passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with PYRUKYND

Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. PYRUKYND and certain other medicines may affect each other causing side effects. PYRUKYND may affect the way other medicines work, and other medicines may affect how PYRUKYND works. Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.

Please see Full Prescribing Information, including Patient Information.