Prescribed PYRUKYND® (mitapivat) tablets?

Here’s how we’ll help you get started:

Your doctor or healthcare professional prescribes PYRUKYND and sends an enrollment form to myAgios Patient Support Services

Your Patient Support Manager will give you a call to help you get started. They’ll listen to your needs and give you personalized tools along the way. Working together, our goal is to help you throughout your journey with PK deficiency and treatment with PYRUKYND

After you and your Patient Support Manager finish your first call, we’ll send you a Welcome Kit in the mail within two weeks. Your Welcome Kit will include brochures about myAgios and PYRUKYND, info on financial support, and instructions on how to stay connected with your Patient Support Managers. PSMs can also help you connect with others with PK deficiency through patient webinar programs, regardless of treatment status

Your doctor or your doctor’s office will fill out forms to help your insurance company process your PYRUKYND prescription.

If you need help accessing PYRUKYND, your doctor or Patient Support Manager can help you find financial support programs that may be able to help

Your doctor or myAgios will let you know how you can get your medication

Looking for financial support?
We have a few programs.

Check them out

We’re ready when you are.

Get answers by calling your Patient Support Manager at 1-800-951-3889, Mon-Fri, 8 AM to 6 PM, ET


PYRUKYND is a prescription medicine used to treat low red blood cell counts caused by the early breakdown of red blood cells (hemolytic anemia) in adults with pyruvate kinase (PK) deficiency.

It is not known if PYRUKYND is safe and effective in children.


PYRUKYND may cause serious side effects, including:

  • Rapid breakdown of red blood cells (acute hemolysis) has happened after suddenly interrupting or stopping treatment with PYRUKYND. You should not suddenly stop taking PYRUKYND. If you have to stop your treatment with PYRUKYND, your healthcare provider should monitor you closely. Tell your healthcare provider right away if you develop any signs or symptoms of breakdown of red blood cells including yellowing of the skin or the whites of your eyes (jaundice), dark colored urine, dizziness, confusion, feeling tired, or shortness of breath

The most common side effects of PYRUKYND were decrease in reproductive hormone (estrone) in men, increased salt from uric acid (urate) blood test, back pain, decrease in reproductive hormone (estradiol) in men, and joint pain (arthralgia).

These are not all the possible side effects of PYRUKYND. Call your healthcare provider for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or

Before taking PYRUKYND, tell your healthcare provider about all of your medical conditions, including if you:

  • have liver problems

  • are pregnant or plan to become pregnant. It is not known if PYRUKYND will harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think that you are pregnant during treatment with PYRUKYND

  • are breastfeeding or plan to breastfeed. It is not known if PYRUKYND passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with PYRUKYND

Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. PYRUKYND and certain other medicines may affect each other causing side effects. PYRUKYND may affect the way other medicines work, and other medicines may affect how PYRUKYND works. Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.

Please see Full Prescribing Information, including Patient Information.